Abstract
Interest in using aneuploidy screening to select embryos has been renewed with the
introduction of new methods for comprehensive chromosome screening (CCS) that evaluate
all 24 chromosomes. With a series of experiments providing level I evidence of accuracy,
reliability, safety, predictive value, and clinical efficacy, CCS-based selection
of a single euploid blastocyst may provide an opportunity to finally realize the potential
benefits and practical application of elective single embryo transfer. Furthermore,
by incorporating CCS into research and development to control for chromosomal contribution
to reproductive potential, additional biomarkers may now be more readily identified
that help to further enhance the efficacy of embryo selection technology. This review
describes the critical components of a valid CCS embryo selection methodology and
discusses the limitations and opportunities for future routine application in reproductive
medicine.
Keywords
comprehensive chromosome screening - preimplantation genetic screening - microarray
- comparative genomic hybridization - single embryo transfer
